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Utility of transbronchial biopsy in the diagnosis of lymphangioleiomyomatosis

Riffat Meraj, Kathryn A. Wikenheiser-Brokamp, Lisa R. Young, Sue Byrnes, Francis X. McCormack

Frontiers of Medicine 2012, Volume 6, Issue 4,   Pages 395-405 doi: 10.1007/s11684-012-0231-5

Abstract:

Pulmonary lymphangioleiomyomatosis (LAM) is a rare cystic lung disease that targets women during theirAlthough surgical lung biopsy is considered the gold standard for obtaining tissue in patients with diffuselung disease, it is also associated with higher morbidity and mortality than alternative, less invasivea safe and effective method for establishing the diagnosis of LAM, obviating the need for surgical lung

Keywords： lymphangioleiomyomatosis     lymphangiomyomatosis     multicystic lung disease     diffuse cystic lung disease     transbronchial    

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Diffuse cystic lung diseases

Jay H. Ryu, Xinlun Tian, Misbah Baqir, Kaifeng Xu

Frontiers of Medicine 2013, Volume 7, Issue 3,   Pages 316-327 doi: 10.1007/s11684-013-0269-z

Abstract: infectious processes such as coccidioidomycosis, Pneumocystis jiroveci pneumonia, and hydatid diseaselymphoid interstitial pneumonia, Birt-Hogg-Dubé syndrome, amyloidosis, light chain deposition diseasedisease.Correlating the tempo of the disease process and clinical context with chest imaging findings serve asimportant clues to defining the underlying nature of the cystic lung disease and guide diagnostic evaluation

Keywords： cyst     lung disease     interstitial lung disease     lymphangioleiomyomatosis     Langerhans’ cell histiocytosis     Birt-Hogg-Dubé    

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Association of cardiac disease with the risk of post-lung transplantation mortality in Chinese recipients

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 58-67 doi: 10.1007/s11684-022-0937-y

Abstract: The current organ allocation rules prioritize elderly and urgent patients on the lung transplantationThis retrospective cohort study recruited 166 lung transplant recipients aged ≥ 65 yearsGroup D restrictive lung disease was the main indication of a lung transplant in recipients over 65 years

Keywords： cardiac disease     mortality     aged population     lung transplantation    

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Ambient air pollution and lung disease in China: health effects, study design approaches and future research

Jeffrey H. Mandel,Christine Wendt,Charles Lo,Guangbiao Zhou,Marshall Hertz,Gurumurthy Ramachandran

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 392-400 doi: 10.1007/s11684-015-0397-8

Abstract: This fraction has been associated with increasing rates of cardio-respiratory disease in China and elsewhereLung cancer mortality in China has increased since the 1970s and has been higher in men and in urban

Keywords： air pollution     PM2.5     lung disease     study design     epidemiology    

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Curbing the burden of lung cancer

Alexandra Urman,H. Dean Hosgood

Frontiers of Medicine 2016, Volume 10, Issue 2,   Pages 228-232 doi: 10.1007/s11684-016-0447-x

Abstract:

Lung cancer contributes substantially to the global burden of disease and healthcare costs.Focusing on prevention is an important factor to reduce the burden of screening, treatment, and lungThe International Agency for Research on Cancer has identified several lung carcinogens, which we believeTo curb the societal burden of lung cancer, healthcare resources need to be focused on early detectionlung cancer.

Keywords： lung cancer     screening     risk factors     environmental    

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FERM domain-containing protein FRMD6 activates the mTOR signaling pathway and promotes lung cancer progression

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 714-728 doi: 10.1007/s11684-022-0959-5

Abstract: Here, we demonstrate the involvement of FRMD6 in lung cancer progression.We find that FRMD6 is overexpressed in lung cancer tissues relative to in normal lung tissues.In addition, the enhanced expression of FRMD6 is associated with poor outcomes in patients with lungsquamous cell carcinoma (n = 75, P = 0.0054) and lung adenocarcinoma (n = 94, lung cancer progression by activating the mTOR

Keywords： FRMD6     lung cancer     mTOR pathway    

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Pathogenesis sequences in Gejiu miners with lung cancer: an introduction

Li Bian,Yonghua Ruan,Liju Ma,Hairong Hua,Li Zhou,Xiaoyu Tuo,Zheyan Zhou,Ting Li,Shiyue Liu,Kewei Jin

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 344-349 doi: 10.1007/s11684-015-0399-6

Abstract:

Tin miners in Gejiu, Yunnan Province, China are at high risk of developing lung cancer with significantpresented pathological characteristics, such as fibroplasia in carcinomas, peri-cancerous tissue in lungOur findings suggested that pulmonary fibrosis may increase the risk and promote the occurrence of lungcancer, which can lead to lung fiber hyperplasia.

Keywords： Yunnan tin mine     miners     lung cancer    

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The epidemic status and risk factors of lung cancer in Xuanwei City, Yunnan Province, China

Yize Xiao, Ying Shao, Xianjun Yu, Guangbiao Zhou

Frontiers of Medicine 2012, Volume 6, Issue 4,   Pages 388-394 doi: 10.1007/s11684-012-0233-3

Abstract: Unfortunately, the lung cancer morbidity and mortality rates in this region are among China’s highestIn 2004–2005, the crude death rate of lung cancer was 91.3 per 100 000 in the whole Xuanwei CityThe epidemiologic distribution (clustering patterns by population, time, and space) of lung cancer inThe main factor that associates with a high rate of lung cancer incidence was found to be indoor airTaken together, lung cancer in this smoky coal combustion region is a unique model for environmental

Keywords： lung cancer     Xuanwei     smoky coal combustion     polycyclic aromatic hydrocarbons     epidemiology    

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Molecular markers and pathogenically targeted therapy in non-small cell lung cancer

Bo PENG BA , Jinnong ZHANG MD , Jamile S. WOODS MD , Wei PENG MD, PhD

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 245-255 doi: 10.1007/s11684-009-0044-3

Abstract: Lung cancer is one of the most common human cancers and the number one cancer killer in the United StatesIn general, lung cancer includes small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC), but NSCLC accounts for approximately 90% of lung cancer.tools, which can improve current early detection to reduce mortality from lung cancer, do not exist.These molecular markers in NSCLC demonstrated close associations with the development of lung cancer

Keywords： lung cancer     carcinoma     non-small cell lung cancer     molecular markers     targeted therapy    

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MicroRNAs and lung cancers: from pathogenesis to clinical implications

Ji Qi, David Mu

Frontiers of Medicine 2012, Volume 6, Issue 2,   Pages 134-155 doi: 10.1007/s11684-012-0188-4

Abstract:

Lung cancer is the leading cause of cancer-related deaths in the US and worldwide.Better understanding of the disease is warranted for improvement in clinical management.functions of small-RNA-based, posttranscriptional gene regulators, i.e. microRNAs, in the pathogenesis of lungmicroRNAs as markers for diagnosis, prognosis and the promising field of microRNA-based novel therapies for lung

Keywords： lung biology     lung cancer     microRNA    

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Outcomes of patients awaiting lung transplantation after the implementation of donation after brain death

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 760-765 doi: 10.1007/s11684-021-0899-5

Abstract: To elaborate the outcomes of patients awaiting lung transplantation (LTx) after the implementation ofafter brain death, we performed a retrospective study that encompassed 205 patients with end-stage lungdisease who registered for LTx at Shanghai Pulmonary Hospital from January 1, 2015 to January 1, 2021Interstitial lung disease (ILD) (103/180, 57.2%) and chronic obstructive pulmonary disease (COPD) (56ILD as primary disease and mPAP > 35 mmHg were two significant independent risk factors for waitlist

Keywords： lung transplantation     donation after brain death     waitlist    

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Clinical factors associated with composition of lung microbiota and important taxa predicting clinical

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 389-402 doi: 10.1007/s11684-021-0856-3

Abstract: Few studies have described the key features and prognostic roles of lung microbiota in patients withvariance found that positive bacteria lab test results had the strongest independent association with lungThe positive bacteria lab test results, AKI, and plasma MIP-1β level were associated with patients’ lung

Keywords： severe community-acquired pneumonia     lung microbiota     clinical improvements     7-category ordinal scale    

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Treatment of advanced non-small cell lung cancer with driver mutations: current applications and future

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 18-42 doi: 10.1007/s11684-022-0976-4

Abstract: With the improved understanding of driver mutations in non-small cell lung cancer (NSCLC), expanding

Keywords： non-small cell lung cancer     driver mutations     treatment strategy     resistant mechanism     immune-checkpoint    

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Lobectomy by video-assisted thoracoscopic surgery (VATS) for early stage of non-small cell lung cancer

Min ZHU, Xiang-Ning FU, Xiao-Ping CHEN

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 53-60 doi: 10.1007/s11684-011-0121-2

Abstract:

Video-assisted thoracoscopic surgery (VATS) provides a new approach for treating early-stage lungHowever, there is still much debate on the role of VATS in lobectomy for the treatment of lung cancerlymph node dissection, and long-term survival have made some surgeons apprehensive of its validity for lungreview the development of thoracoscopy, the present status of VATS for early stage of non-small cell lung

Keywords： non-small cell lung cancer     video-assisted thoracoscopic surgery     lobectomy    

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Anlotinib as third- or further-line therapy for short-term relapsed small-cell lung cancer: subgroup

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 766-772 doi: 10.1007/s11684-021-0916-8

Abstract: Patients with small-cell lung cancer (SCLC) relapse within months after completing previous therapiesPatients with short-term relapsed SCLC (disease progression within 3 months after completing ≥ two linesThe secondary endpoints included overall survival, objective response rate (ORR), disease control rate

Keywords： anlotinib     chemotherapy     short-term relapsed     small-cell lung cancer    

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Title Author Date Type Operation

Utility of transbronchial biopsy in the diagnosis of lymphangioleiomyomatosis

Riffat Meraj, Kathryn A. Wikenheiser-Brokamp, Lisa R. Young, Sue Byrnes, Francis X. McCormack

Journal Article

Diffuse cystic lung diseases

Jay H. Ryu, Xinlun Tian, Misbah Baqir, Kaifeng Xu

Journal Article

Association of cardiac disease with the risk of post-lung transplantation mortality in Chinese recipients

Journal Article

Ambient air pollution and lung disease in China: health effects, study design approaches and future research

Jeffrey H. Mandel,Christine Wendt,Charles Lo,Guangbiao Zhou,Marshall Hertz,Gurumurthy Ramachandran

Journal Article

Curbing the burden of lung cancer

Alexandra Urman,H. Dean Hosgood

Journal Article

FERM domain-containing protein FRMD6 activates the mTOR signaling pathway and promotes lung cancer progression

Journal Article

Pathogenesis sequences in Gejiu miners with lung cancer: an introduction

Li Bian,Yonghua Ruan,Liju Ma,Hairong Hua,Li Zhou,Xiaoyu Tuo,Zheyan Zhou,Ting Li,Shiyue Liu,Kewei Jin

Journal Article

The epidemic status and risk factors of lung cancer in Xuanwei City, Yunnan Province, China

Yize Xiao, Ying Shao, Xianjun Yu, Guangbiao Zhou

Journal Article

Molecular markers and pathogenically targeted therapy in non-small cell lung cancer

Bo PENG BA , Jinnong ZHANG MD , Jamile S. WOODS MD , Wei PENG MD, PhD

Journal Article

MicroRNAs and lung cancers: from pathogenesis to clinical implications

Ji Qi, David Mu

Journal Article

Outcomes of patients awaiting lung transplantation after the implementation of donation after brain death

Journal Article

Clinical factors associated with composition of lung microbiota and important taxa predicting clinical

Journal Article

Treatment of advanced non-small cell lung cancer with driver mutations: current applications and future

Journal Article

Lobectomy by video-assisted thoracoscopic surgery (VATS) for early stage of non-small cell lung cancer

Min ZHU, Xiang-Ning FU, Xiao-Ping CHEN

Journal Article

Anlotinib as third- or further-line therapy for short-term relapsed small-cell lung cancer: subgroup

Journal Article